Pub. Date : 2000 Aug 1
PMID : 10903761
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chloroquine interferes with lipopolysaccharide-induced TNF-alpha gene expression by a nonlysosomotropic mechanism. | Chloroquine | tumor necrosis factor | Homo sapiens |
| 2 | Consistent with its anti-inflammatory properties, CQ has been shown to interfere with TNF-alpha release from mononuclear phagocytes. | Chloroquine | tumor necrosis factor | Homo sapiens |
| 3 | CQ exhibited dose-dependent inhibition of LPS-induced TNF-alpha release from human PBMC at therapeutically attainable concentrations. | Chloroquine | tumor necrosis factor | Homo sapiens |
| 4 | CQ acted by reducing TNF-alpha mRNA accumulation without destabilizing its mRNA or interfering with NF-kappaB nuclear translocation or p50/p65 isoform composition of DNA-binding complexes. | Chloroquine | tumor necrosis factor | Homo sapiens |
| 5 | Intracellular cytokine staining indicated that CQ reduced TNF-alpha production pretranslationally without interfering with TNF-alpha processing or release. | Chloroquine | tumor necrosis factor | Homo sapiens |
| 6 | Although bafilomycin A1 alone did not interfere with TNF-alpha expression, preincubation augmented the ability of CQ to reduce TNF-alpha mRNA levels, suggesting that CQ did not act by a lysosomotropic mechanism. | Chloroquine | tumor necrosis factor | Homo sapiens |
| 7 | These data indicate that CQ inhibits TNF-alpha gene expression without altering translocation of NF-kappaB p50/p65 heterodimers. | Chloroquine | tumor necrosis factor | Homo sapiens |