Title : Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies.

Pub. Date : 2000 Aug

PMID : 10891502






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The present experiments, performed with an extensive panel of site-directed mutations within each of the six kelch motifs, further support the critical role of both hydrophobic and glycine-rich regions within the second beta-strand for RAG1-RAG2 interaction and recombination signal recognition and cleavage. Glycine recombination activating 1 Homo sapiens