Title : Induction of oxidative DNA damage in u937 cells by TNF or anti-Fas stimulation.

Pub. Date : 2000 Jul

PMID : 10880232






2 Functional Relationships(s)
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1 Cytogenetic analysis showed that, in the presence of aphidicolin, which blocks several types of DNA repair, TNF induced extensive chromosomal damage. Aphidicolin tumor necrosis factor Homo sapiens
2 Aphidicolin also synergized with TNF and anti-Fas in inducing cell death which was prevented by reducing atmospheric oxygen or addition of n -acetyl cysteine, a scavenger of oxygen radicals. Aphidicolin tumor necrosis factor Homo sapiens