Title : Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines.

Pub. Date : 2000 May

PMID : 10866285






1 Functional Relationships(s)
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1 PURPOSE: This study tests the hypothesis that p53 status, i.e. wild type versus mutant form, is a determinant in radiation protection of human glioma cells by WR-1065, the active thiol form of amifostine (WR-2721). Sulfhydryl Compounds tumor protein p53 Homo sapiens