Title : Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats.

Pub. Date : 2000 Jul

PMID : 10859158






2 Functional Relationships(s)
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1 The formation of III was inhibited to a significant extent by carbon monoxide, metyrapone, SKF 525-A, and cytochrome c, suggesting the participation of PB-induced microsomal cytochrome P-450 system in the conversion of I to III. Phenobarbital cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 This suggests that PB-induced cytochrome P-450-catalyzed reactive metabolites may be responsible for the toxic effects caused by I. Phenobarbital cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus