Title : Designing small-molecule switches for protein-protein interactions.

Pub. Date : 2000 Jun 16

PMID : 10856217






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Mutations introduced into human growth hormone (hGH) (Thr175 --> Gly-hGH) and the extracellular domain of the hGH receptor (Trp104 --> Gly-hGHbp) created a cavity at the protein-protein interface that resulted in binding affinity being reduced by a factor of 10(6). Glycine growth hormone receptor Homo sapiens
2 Mutations introduced into human growth hormone (hGH) (Thr175 --> Gly-hGH) and the extracellular domain of the hGH receptor (Trp104 --> Gly-hGHbp) created a cavity at the protein-protein interface that resulted in binding affinity being reduced by a factor of 10(6). Glycine growth hormone receptor Homo sapiens