Title : Significance of tau phosphorylation and protein kinase regulation in the pathogenesis of Alzheimer disease.

Pub. Date : 2000

PMID : 10850726






1 Functional Relationships(s)
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1 In cells treated with wortmannin, protein kinase C delta fragments were observed, and the protein kinase C activity increased after 3 hours, whereas treatment of cells with z-DEVD-fmk, an inhibitor of caspase-3, inhibited fragmentation of protein kinase C delta and induced continuous activation of GSK-3. Wortmannin caspase 3 Homo sapiens