Title : Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer.

Pub. Date : 2000 Jun 1

PMID : 10850453






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Whereas pharmacological inhibitors of various mitogenic signaling pathways showed no effects, blockade of the mitogen-activated protein kinase (MAPK) pathway by the MAPK kinase 1 inhibitor PD98059 restored the growth inhibitory role of TGF-beta1 in TSU-Pr1, which carries an oncogenic mutation in Ha-Ras (V12). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor beta 1 Homo sapiens