Pub. Date : 2000 Sep 8
PMID : 10842184
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrated previously that growth hormone (GH) induces tyrosyl phosphorylation of SIRPalpha and association of SIRPalpha with SHP-2. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 2 | We demonstrated previously that growth hormone (GH) induces tyrosyl phosphorylation of SIRPalpha and association of SIRPalpha with SHP-2. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 3 | The GH-activated tyrosine kinase JAK2 associates with and tyrosyl-phosphorylates SIRPalpha1. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 4 | GH-dependent tyrosyl phosphorylation of JAK2 is reduced when wild-type SIRPalpha1 compared with SIRPalpha1 lacking the four cytoplasmic tyrosines (SIRP 4YF) is expressed in cells, suggesting that SIRPalpha1 negatively regulates GHR/JAK2 signaling. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |