Title : Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.

Pub. Date : 2000 Jun 1

PMID : 10841792

1 Functional Relationships(s)
Compound Name
Protein Name
1 Stabilization of lead compounds against cathepsin B cleavage by N-methylation of noncritical backbone NH groups or by dipeptide mimetic substitutions has generated analogues that compete effectively against protein antigens in cellular assays, resulting in inhibition of T-cell proliferation. Dipeptides cathepsin B Homo sapiens