Pub. Date : 2000 Jun
PMID : 10828252
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of IRK1 channel block by intracellular polyamines. | Polyamines | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 2 | Intracellular polyamines inhibit the strongly rectifying IRK1 potassium channel by a mechanism different from that of a typical ionic pore blocker such as tetraethylammonium. | Polyamines | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 3 | Furthermore, contrary to the expectation for a nonpermeant ionic pore blocker, a significant residual IRK1 current persists at very positive membrane voltages; the amplitude of the residual current decreases with increasing polyamine concentration. | Polyamines | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 4 | This complex blocking behavior of polyamines can be accounted for by a minimal model whereby intracellular polyamines inhibit the IRK1 channel by inducing two blocked channel states. | Polyamines | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 5 | This complex blocking behavior of polyamines can be accounted for by a minimal model whereby intracellular polyamines inhibit the IRK1 channel by inducing two blocked channel states. | Polyamines | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 6 | The proposal that polyamines traverse the pore at finite rates is supported by the observation that philanthotoxin-343 (spermine with a bulky chemical group attached to one end) acts as a nonpermeant ionic blocker in the IRK1 channel. | Polyamines | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |