Title : Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).

Pub. Date : 2000 May 9

PMID : 10820001






1 Functional Relationships(s)
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1 Transition state analogue boronic acid inhibitors mimicking the structures and interactions of good penicillin substrates for the TEM-1 beta-lactamase of Escherchia coli were designed using graphic analyses based on the enzyme"s 1.7 A crystallographic structure. Boronic Acids TEM-1 beta-lactamase Escherichia coli