Pub. Date : 2000 Jul 28
PMID : 10816560
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. | adenosine nucleotide | heat shock protein 90 beta family member 1 | Homo sapiens |
| 2 | Although this domain is essential for Hsp90 function, the molecular basis for adenosine nucleotide-dependent regulation of GRP94, the endoplasmic reticulum paralog of Hsp90, remains to be established. | adenosine nucleotide | heat shock protein 90 beta family member 1 | Homo sapiens |
| 3 | We report that bis-ANS (1,1"-bis(4-anilino-5-napthalenesulfonic acid), an environment sensitive fluorophore known to interact with nucleotide-binding domains, binds to the adenosine nucleotide-binding domain of GRP94 and thereby activates its molecular chaperone and peptide binding activities. | adenosine nucleotide | heat shock protein 90 beta family member 1 | Homo sapiens |
| 4 | bis-ANS activation of GRP94 function was efficiently blocked by radicicol, an established inhibitory ligand for the adenosine nucleotide binding pocket. | adenosine nucleotide | heat shock protein 90 beta family member 1 | Homo sapiens |