Title : The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.

Pub. Date : 2000 Feb

PMID : 10816095






3 Functional Relationships(s)
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1 Previous work has shown that the basic leucine zipper transcription factor Nrf2 is involved in induction of GST by the phenolic antioxidant butylated hydroxyanisole (BHA). Butylated Hydroxyanisole hematopoietic prostaglandin D synthase Mus musculus
2 Previous work has shown that the basic leucine zipper transcription factor Nrf2 is involved in induction of GST by the phenolic antioxidant butylated hydroxyanisole (BHA). Butylated Hydroxyanisole hematopoietic prostaglandin D synthase Mus musculus
3 In the Nrf2 knock-out mouse, hepatic induction of class Alpha and class Mu GST by BHA and the synthetic antioxidant ethoxyquin is similarly impaired, suggesting that these agents affect gene activation by a related mechanism. Butylated Hydroxyanisole hematopoietic prostaglandin D synthase Mus musculus