Title : Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.

Pub. Date : 2000 May 9

PMID : 10805771






1 Functional Relationships(s)
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1 The architecturally stabilized closing of UDG enforces distortions of the uracil and deoxyribose in the flipped-out nucleotide substrate that are relieved by glycosylic bond cleavage in the product complex. Deoxyribose uracil DNA glycosylase Homo sapiens