Title : Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme.

Pub. Date : 2000 May 12

PMID : 10799547






1 Functional Relationships(s)
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1 We found that TACE must be expressed with its membrane-anchoring domain for phorbol ester-stimulated shedding of TNF, p75 TNFR, and IL-1R-II, but that the cytoplasmic domain is not required for the shedding of these substrates. Phorbol Esters tumor necrosis factor Homo sapiens