Title : Interleukin-6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex.

Pub. Date : 2000 Apr

PMID : 10762353






1 Functional Relationships(s)
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1 We have found that IL-6 depresses the spread of excitation and evoked glutamate release in the cerebral cortex, and that these effects are accompanied by a stimulation of STAT3 tyrosine phosphorylation, an inhibition of MAPK/ERK activity, a decreased phosphorylation of the presynaptic MAPK/ERK substrate synapsin I and no detectable effects on SAPK/JNK. Tyrosine signal transducer and activator of transcription 3 Rattus norvegicus