Pub. Date : 2000 Apr 12
PMID : 10760475
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thus, human brain SCHAD may function in androgen metabolism as a new kind of 3alpha-HSD by counteracting all other known 3alpha-HSDs, which would unidirectionally catalyze the reduction of DHT to the almost inactive 3alpha-adiol. | Dihydrotestosterone | aldo-keto reductase family 1 member C4 | Homo sapiens |
| 2 | This study represents the first report of a 3alpha-HSD that could act to generate DHT from 3alpha-adiol and thereby maintain intracellular DHT levels. | Dihydrotestosterone | aldo-keto reductase family 1 member C4 | Homo sapiens |
| 3 | This study represents the first report of a 3alpha-HSD that could act to generate DHT from 3alpha-adiol and thereby maintain intracellular DHT levels. | Dihydrotestosterone | aldo-keto reductase family 1 member C4 | Homo sapiens |
| 4 | We propose that inhibitors of the 3alpha-HSD activity of human brain SCHAD could be useful for the treatment of benign prostatic hyperplasia and other disorders involving DHT metabolism, in combination with known inhibitors of steroid 5alpha-reductases. | Dihydrotestosterone | aldo-keto reductase family 1 member C4 | Homo sapiens |