Title : Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility.

Pub. Date : 2000 Apr 7

PMID : 10744661






1 Functional Relationships(s)
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1 In alpha-toxin-permeabilized strips at pCa 6.7, contractile force and CPI-17 phosphorylation were proportional in response to histamine, guanosine 5"-O-(gamma-thiotriphosphate), and histamine plus guanyl-5"-yl thiophosphate, implying that histamine increased CPI-17 phosphorylation through activation of G proteins. guanosine 5'-O-(2-thiodiphosphate) protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens