Title : Expression of monocyte chemoattractant protein-1 by nonenzymatically glycated albumin (Amadori adducts) in vascular smooth muscle cells.

Pub. Date : 2000 Mar 24

PMID : 10720473






4 Functional Relationships(s)
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1 The induction of MCP-1 by GA was dose-dependent. Gallium C-C motif chemokine ligand 2 Homo sapiens
2 The MCP-1 mRNA expression by GA was completely inhibited by PD98059 and genistein that inhibit mitogen activated protein (MAP) kinase kinase and tyrosine kinase, respectively. Gallium C-C motif chemokine ligand 2 Homo sapiens
3 N-Acetylcysteine, a potent antioxidant, also suppressed the GA-induced MCP-1 expression. Gallium C-C motif chemokine ligand 2 Homo sapiens
4 GA-induced MCP-1 expression may be one of the mechanisms by which the diabetic patients suffer from accelerated atherosclerosis. Gallium C-C motif chemokine ligand 2 Homo sapiens