Pub. Date : 2000 Feb
PMID : 10711350
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both thapsigargin (30 nM) and TPA (30 nM) induced phosphorylation of p44/p42 MAP kinase and p38 MAP kinase. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | PD98059, a specific inhibitor of MEK-1 which phosphorylates p44/p42 MAP kinase, strongly suppressed both the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production, whereas SB203580, a specific inhibitor of p38 MAP kinase, inhibited them only partially. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 3 | Mus musculus |