Pub. Date : 2000 Feb
PMID : 10690900
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To address potential TGFbeta1 induction by DHT, quantitative PCR and enzyme-linked immunoadsorbent assay were performed in NCI-H295 cells treated with DHT (from 10(-12)-10(-9) mol/L). | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 2 | DHT led to a significant dose-dependent increase in TGFbeta1 messenger ribonucleic acid expression and in biologically active TGFbeta1 protein levels in the conditioned media of NCI-H295 cells, demonstrating that androgen can induce TGFbeta1 expression and production. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 3 | DHT led to a significant dose-dependent increase in TGFbeta1 messenger ribonucleic acid expression and in biologically active TGFbeta1 protein levels in the conditioned media of NCI-H295 cells, demonstrating that androgen can induce TGFbeta1 expression and production. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 4 | DHT led to a significant dose-dependent increase in TGFbeta1 messenger ribonucleic acid expression and in biologically active TGFbeta1 protein levels in the conditioned media of NCI-H295 cells, demonstrating that androgen can induce TGFbeta1 expression and production. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 5 | The addition of TGFbeta1-neutralizing antibody to cell cultures treated with different DHT concentrations (10(-9) and 10(-10) mol/L) blocked the inhibitory effect of TGF/beta1 on adrenocortical cell proliferation. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 6 | The addition of TGFbeta1-neutralizing antibody to cell cultures treated with different DHT concentrations (10(-9) and 10(-10) mol/L) blocked the inhibitory effect of TGF/beta1 on adrenocortical cell proliferation. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |
| 7 | Therefore, it might be reasonable to suppose that DHT could also influence human adrenocortical cell growth by involving TGFbeta1. | Dihydrotestosterone | transforming growth factor beta 1 | Homo sapiens |