Title : Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos.

Pub. Date : 2000 Jan 14

PMID : 10681099






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1 Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos. Oximes acetylcholinesterase (Cartwright blood group) Gallus gallus
2 Organophosphorous (OP) insecticide-induced inhibition and oxime reactivation of acetylcholinesterase (AChE) was determined in whole-brain homogenates prepared from 15-d-old chick embryos. Oximes acetylcholinesterase (Cartwright blood group) Gallus gallus
3 Organophosphorous (OP) insecticide-induced inhibition and oxime reactivation of acetylcholinesterase (AChE) was determined in whole-brain homogenates prepared from 15-d-old chick embryos. Oximes acetylcholinesterase (Cartwright blood group) Gallus gallus
4 Following insecticide exposure, an in vitro system compared the capability of the oximes pralidoxime (2-PAM), obidoxime, TMB-4, and HI-6 to reactivate the OP-inhibited AChE. Oximes acetylcholinesterase (Cartwright blood group) Gallus gallus
5 These results suggest that both the OP insecticide inhibiting AChE and the oxime reactivating this enzyme can contribute to the effectiveness of the avian brain AChE reactivation. Oximes acetylcholinesterase (Cartwright blood group) Gallus gallus