Title : Type I consensus interferon (CIFN) gene transfer into human melanoma cells up-regulates p53 and enhances cisplatin-induced apoptosis: implications for new therapeutic strategies with IFN-alpha.

Pub. Date : 2000 Jan

PMID : 10673721






1 Functional Relationships(s)
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1 The increased susceptibility of the IFN-producing melanoma cell lines to cisplatin-induced apoptosis was associated with an IFN-dependent accumulation of p53, which also correlated with a decrease in Bcl-2 expression. Cisplatin transformation related protein 53, pseudogene Mus musculus