Pub. Date : 2000 Feb
PMID : 10671903
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | CONCLUSIONS: It has previously been postulated that individuals genetically deficient for the hepatic enzyme CYP2D6 (about 10% of the Caucasian people) were at risk of developing acute toxicity at moderate doses of MDMA because the drug would accumulate in the body instead of being metabolized and inactivated. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
2 | The lack of linearity of MDMA pharmacokinetics (in a window of doses compatible with its recreational use) is a more general phenomenon as it concerns the whole population independent of their CYP2D6 genotype. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |