Title : Non-linear pharmacokinetics of MDMA ('ecstasy') in humans.

Pub. Date : 2000 Feb

PMID : 10671903






2 Functional Relationships(s)
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1 CONCLUSIONS: It has previously been postulated that individuals genetically deficient for the hepatic enzyme CYP2D6 (about 10% of the Caucasian people) were at risk of developing acute toxicity at moderate doses of MDMA because the drug would accumulate in the body instead of being metabolized and inactivated. N-Methyl-3,4-methylenedioxyamphetamine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 The lack of linearity of MDMA pharmacokinetics (in a window of doses compatible with its recreational use) is a more general phenomenon as it concerns the whole population independent of their CYP2D6 genotype. N-Methyl-3,4-methylenedioxyamphetamine cytochrome P450 family 2 subfamily D member 6 Homo sapiens