Title : Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences.

Pub. Date : 2000 Jan

PMID : 10668786






5 Functional Relationships(s)
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1 We now obtained evidence that L-plastin gene expression was positively regulated by testosterone in androgen receptor (AR)-positive prostate and breast cancer cells. Testosterone androgen receptor Homo sapiens
2 We now obtained evidence that L-plastin gene expression was positively regulated by testosterone in androgen receptor (AR)-positive prostate and breast cancer cells. Testosterone androgen receptor Homo sapiens
3 Their testosterone/AR responsiveness became evident only when two or three of them were combined. Testosterone androgen receptor Homo sapiens
4 Thus, the three L-plastin AREs, despite their imperfect sequences compared with the consensus ARE, could cooperate with each other to become a potent testosterone/AR-responsive unit, which was likely responsible for the inducibility of the L-plastin gene by testosterone. Testosterone androgen receptor Homo sapiens
5 Thus, the three L-plastin AREs, despite their imperfect sequences compared with the consensus ARE, could cooperate with each other to become a potent testosterone/AR-responsive unit, which was likely responsible for the inducibility of the L-plastin gene by testosterone. Testosterone androgen receptor Homo sapiens