Title : Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.

Pub. Date : 2000 Jan 15

PMID : 10667562






6 Functional Relationships(s)
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1 Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates. benzyl isothiocyanate hematopoietic prostaglandin D synthase Rattus norvegicus
2 Here we report the molecular mechanism underlying the induction of glutathione S-transferase (GST) in rat liver epithelial RL34 cells treated with a cancer chemopreventive isothiocyanate compound, benzylisothiocyanate (BITC). benzyl isothiocyanate hematopoietic prostaglandin D synthase Rattus norvegicus
3 Here we report the molecular mechanism underlying the induction of glutathione S-transferase (GST) in rat liver epithelial RL34 cells treated with a cancer chemopreventive isothiocyanate compound, benzylisothiocyanate (BITC). benzyl isothiocyanate hematopoietic prostaglandin D synthase Rattus norvegicus
4 Here we report the molecular mechanism underlying the induction of glutathione S-transferase (GST) in rat liver epithelial RL34 cells treated with a cancer chemopreventive isothiocyanate compound, benzylisothiocyanate (BITC). benzyl isothiocyanate hematopoietic prostaglandin D synthase Rattus norvegicus
5 Here we report the molecular mechanism underlying the induction of glutathione S-transferase (GST) in rat liver epithelial RL34 cells treated with a cancer chemopreventive isothiocyanate compound, benzylisothiocyanate (BITC). benzyl isothiocyanate hematopoietic prostaglandin D synthase Rattus norvegicus
6 Furthermore, glutathione depletion by diethyl maleate significantly enhanced BITC-induced ROI production and accelerated the BITC-induced elevation of the GST activity, whereas pretreatment of the cells with glutathione inhibited both the ROI production and GST induction. benzyl isothiocyanate hematopoietic prostaglandin D synthase Rattus norvegicus