Title : Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcription.

Pub. Date : 2000 Mar

PMID : 10666284






3 Functional Relationships(s)
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1 IFN-alpha-stimulated tyrosine phosphorylation of STATs and subsequent formation of the IFN-stimulated gene factor 3 transcription complex were inhibited in SeV-infected cells, resulting in inefficient induction of IFN-stimulated gene products. Tyrosine interferon alpha 1 Homo sapiens
2 Moreover, tyrosine phosphorylation of Jak1 in response to IFN-alpha was unaffected at the early phase of infection, suggesting that oligomerization of the receptor subunits proceeded normally. Tyrosine interferon alpha 1 Homo sapiens
3 In contrast to Jak1, IFN-alpha-stimulated tyrosine phosphorylation of Tyk2 was partially inhibited. Tyrosine interferon alpha 1 Homo sapiens