Title : The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

Pub. Date : 2000 Feb 4

PMID : 10652295






1 Functional Relationships(s)
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1 The transition of rhodopsin from the inactive to the active state is associated with proton uptake at Glu(134) (1), and recent mutagenesis studies suggest that protonation of the homologous amino acid in the alpha(1B) adrenergic receptor (Asp(142)) may be involved in its mechanism of activation (2). Aspartic Acid rhodopsin Homo sapiens