Pub. Date : 2000 Feb
PMID : 10651981
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. | Dinoprostone | xeroderma pigmentosum, complementation group A | Mus musculus |
| 2 | In XPA-deficient mice, the amount of PGE2 significantly increased at 48 and 72 h after UVB irradiation to the level that was 8- and 16-fold higher than those in wild-type mice, respectively. | Dinoprostone | xeroderma pigmentosum, complementation group A | Mus musculus |
| 3 | Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited UV-induced ear swelling, abrogated local immunosuppression, and decreased the amount of PGE2 in the ear skin of XPA-deficient mice. | Dinoprostone | xeroderma pigmentosum, complementation group A | Mus musculus |
| 4 | The induced production of PGE2 may be involved in the enhanced inflammation and immunosuppression caused by UV radiation in XPA-deficient mice and XP patients. | Dinoprostone | xeroderma pigmentosum, complementation group A | Mus musculus |