Title : Facilitation of constitutive alpha(2A)-adrenoceptor activity by both single amino acid mutation (Thr(373)Lys) and g(alphao) protein coexpression: evidence for inverse agonism.

Pub. Date : 2000 Feb

PMID : 10640303






1 Functional Relationships(s)
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1 The basal [(35)S]GTPgammaS binding response displayed a constitutive alpha(2A)-AR activity that amounted to 21% of the maximal receptor activation as obtained with 10 microM (-)-adrenaline. Epinephrine adrenoceptor alpha 2A Homo sapiens