Title : Analysis of oxidative DNA damage and HPRT mutant frequencies in cancer patients before and after radiotherapy.

Pub. Date : 1999 Dec 17

PMID : 10636001






2 Functional Relationships(s)
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1 The frequency of hypoxanthine-guanine-phosphoribosyltransferase (HPRT) mutant lymphocytes measured as 6-thioguanine resistant variant cells by 5-bromodeoxyuridine labeling, was elevated eight-fold, from 4.7 x 10(-6) to 36.2 x 10(-6) (p = 0.008) after termination of the radiotherapy, thus showing a clear response to the radiation treatment. Thioguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens
2 The frequency of hypoxanthine-guanine-phosphoribosyltransferase (HPRT) mutant lymphocytes measured as 6-thioguanine resistant variant cells by 5-bromodeoxyuridine labeling, was elevated eight-fold, from 4.7 x 10(-6) to 36.2 x 10(-6) (p = 0.008) after termination of the radiotherapy, thus showing a clear response to the radiation treatment. Thioguanine hypoxanthine phosphoribosyltransferase 1 Homo sapiens