Title : Lesion of the substantia nigra pars compacta downregulates striatal glutamate receptor subunit mRNA expression.

Pub. Date : 1999 Dec 11

PMID : 10629751






3 Functional Relationships(s)
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1 This is a study of the effect of the unilateral administration of dopamine (DA) in the pars compacta of the substantia nigra (SN) of the rat on striatal glutamate receptor subunit (GluR1, GluR2 and NMDAR1) gene expression determined by in situ hybridization. Dopamine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus
2 This is a study of the effect of the unilateral administration of dopamine (DA) in the pars compacta of the substantia nigra (SN) of the rat on striatal glutamate receptor subunit (GluR1, GluR2 and NMDAR1) gene expression determined by in situ hybridization. Dopamine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus
3 The DA-induced lesions produce significant bilateral reductions in the expression of GluR1 and NMDAR1 subunit mRNA in the medio-lateral striatum, whereas the expression of striatal GluR2 receptors was not changed. Dopamine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus