Title : The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation.

Pub. Date : 1999 Dec 16

PMID : 10618719






1 Functional Relationships(s)
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1 Thus, we have taken the minimum CDC42-binding domain (residues 504 - 545, called ACK42) of the Tyr-kinase ACK-1 that binds only CDC42 in the GTP-bound form, and thereby blocking the interactions of CDC42-GTP with its downstream effectors such as ACKs, PAKs and N-WASP. Guanosine Triphosphate WASP like actin nucleation promoting factor Rattus norvegicus