Pub. Date : 2000 Feb
PMID : 10617910
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Improving effects of topical administration of iganidipine, a new calcium channel blocker, on the impaired visual evoked potential after endothelin-1 injection into the vitreous body of rabbits. | iganidipine | endothelin-1 | Oryctolagus cuniculus |
| 2 | PURPOSE: To investigate the effect of topical iganidipine, a new dihydropyridine derivative calcium channel blocker, on impairment of the ocular circulation caused by endothelin-1 (ET-1), we examined modification of the effect of ET-1 on visual-evoked potential (VEP) in albino rabbits. | iganidipine | endothelin-1 | Oryctolagus cuniculus |
| 3 | PURPOSE: To investigate the effect of topical iganidipine, a new dihydropyridine derivative calcium channel blocker, on impairment of the ocular circulation caused by endothelin-1 (ET-1), we examined modification of the effect of ET-1 on visual-evoked potential (VEP) in albino rabbits. | iganidipine | endothelin-1 | Oryctolagus cuniculus |
| 4 | Then modification of the effect of ET-1 on the VEP by iganidipine was examined. | iganidipine | endothelin-1 | Oryctolagus cuniculus |
| 5 | One hour after the topical instillation of 0.1% iganidipine (20 microl) or its vehicle, 10 pmol of ET-1 was injected into the vitreous in rabbits. | iganidipine | endothelin-1 | Oryctolagus cuniculus |
| 6 | Topical administration of 0.1% iganidipine significantly suppressed the reduction of VEP amplitude for the entire 2-hour monitoring period after intravitreal injection of 10 pmol ET-1. | iganidipine | endothelin-1 | Oryctolagus cuniculus |
| 7 | CONCLUSIONS: Iganidipine eyedrops may be useful for the treatment of ischemic retinal and optic nerve disorders related to abnormal ET-1 production for the maintenance of visual function. | iganidipine | endothelin-1 | Oryctolagus cuniculus |