Title : Time- and dose-related interactions between glucocorticoid and cyclic adenosine 3',5'-monophosphate on CCAAT/enhancer-binding protein-dependent insulin-like growth factor I expression by osteoblasts.

Pub. Date : 2000 Jan

PMID : 10614631






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 One important bone growth factor, insulin-like growth factor I (IGF-I), is induced in osteoblasts by hormones such as PGE2 that increase intracellular cAMP levels. Dinoprostone insulin like growth factor 1 Homo sapiens
2 One important bone growth factor, insulin-like growth factor I (IGF-I), is induced in osteoblasts by hormones such as PGE2 that increase intracellular cAMP levels. Dinoprostone insulin like growth factor 1 Homo sapiens
3 In this way, PGE2 activates transcription factor CCAAT/enhancer-binding protein-delta (C/EBPdelta) and enhances its binding to a specific control element found in exon 1 in the IGF-I gene. Dinoprostone insulin like growth factor 1 Homo sapiens
4 Our current studies show that preexposure to glucocorticoid enhanced C/EBPdelta and C/EBPbeta expression by osteoblasts and thereby potentiated IGF-I gene promoter activation in response to PGE2. Dinoprostone insulin like growth factor 1 Homo sapiens