Title : The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation.

Pub. Date : 2000 Jan 1

PMID : 10604992






1 Functional Relationships(s)
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1 Specifically, inhibition of extracellular signal-regulated kinase (ERK) activation and of IL-2 production by CTLA-4-mediated signaling occurs in T cells expressing mutant CTLA-4 molecules lacking the cytoplasmic tyrosine residues, and in lck-deficient or ZAP-70-deficient T cells. Tyrosine interleukin 2 Homo sapiens