Pub. Date : 1999 Dec 24
PMID : 10601257
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation of alpha-actinin in activated platelets. | Tyrosine | actinin alpha 1 | Homo sapiens |
| 2 | Furthermore, in the course of this purification, a 105-kDa tyrosine-phosphorylated protein was only detected in fractions that contained alpha-actinin. | Tyrosine | actinin alpha 1 | Homo sapiens |
| 3 | alpha-Actinin resolved by two-dimensional gel electrophoresis of activated platelet lysates was recognized by the antibodies to phosphotyrosine, whereas pretreatment of the platelets with bisindolylmaleimide, a protein kinase C inhibitor that prevents tyrosine phosphorylation of pp105, inhibited the reactivity of the antibodies to phosphotyrosine with alpha-actinin. | Tyrosine | actinin alpha 1 | Homo sapiens |
| 4 | Taken together, these data demonstrate that a fraction of alpha-actinin is tyrosine-phosphorylated in activated platelets. | Tyrosine | actinin alpha 1 | Homo sapiens |