Title : Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate.

Pub. Date : 1999 Nov

PMID : 10598750






2 Functional Relationships(s)
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1 In the present study the salicylate-hydroxylation assay was used to examine whether CYP induction by the administration of dexamethasone, phenobarbital or beta-naphthoflavone to the male rat led to oxidative stress in vivo. Phenobarbital cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 Phenobarbital led to a 4.7-fold increase in 2,3-DHB plasma concentration under conditions that induced CYP P4502B and 3A. Phenobarbital cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus