Title : Suppression of N-methyl-N'-nitro-N-nitrosoguanidine- and S-nitrosoglutathione-induced apoptosis by Bcl-2 through inhibiting glutathione-S-transferase pi in NIH3T3 cells.

Pub. Date : 1999 Nov 22

PMID : 10597028






4 Functional Relationships(s)
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1 Suppression of N-methyl-N"-nitro-N-nitrosoguanidine- and S-nitrosoglutathione-induced apoptosis by Bcl-2 through inhibiting glutathione-S-transferase pi in NIH3T3 cells. S-Nitrosoglutathione B cell leukemia/lymphoma 2 Mus musculus
2 Bcl-2-expressing NIH3T3 prevented N-methyl-N"-nitro-N-nitrosoguanidine (MNNG)- and S-nitrosoglutathione (GSNO)-induced apoptosis as compared with the control NIH3T3 cells. S-Nitrosoglutathione B cell leukemia/lymphoma 2 Mus musculus
3 Bcl-2-expressing NIH3T3 prevented N-methyl-N"-nitro-N-nitrosoguanidine (MNNG)- and S-nitrosoglutathione (GSNO)-induced apoptosis as compared with the control NIH3T3 cells. S-Nitrosoglutathione B cell leukemia/lymphoma 2 Mus musculus
4 Furthermore, both MNNG- and GSNO-induced apoptosis of NIH3T3 cells were accompanied with a decrease in the level of glutathione (GSH); whereas Bcl-2 overexpression led to an increase in total cellular glutathione. S-Nitrosoglutathione B cell leukemia/lymphoma 2 Mus musculus