Pub. Date : 1999 Dec 17
PMID : 10593965
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of a glutathione S-transferase-IkappaBalpha fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is inhibited by 5-ASA. | Mesalamine | conserved helix-loop-helix ubiquitous kinase | Mus musculus |
| 2 | Recombinant IKKalpha and IKKbeta autophosphorylation and their phosphorylation of glutathione S-transferase-IkappaBalpha are inhibited by 5-ASA. | Mesalamine | conserved helix-loop-helix ubiquitous kinase | Mus musculus |
| 3 | In summary, 5-ASA inhibits TNFalpha-stimulated IKKalpha kinase activity toward IkappaBalpha in intestinal epithelial cells. | Mesalamine | conserved helix-loop-helix ubiquitous kinase | Mus musculus |