Title : The human renin infused rat: use as an in vivo model for the biological evaluation of human renin inhibitors.

Pub. Date : 1999 Nov

PMID : 10593662






1 Functional Relationships(s)
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1 A series of peptidomimetic P2-P3 butanediamide renin inhibitors inhibited purified recombinant human renin in vitro in a concentration-dependent manner, with IC50 values ranging from 0.4 to 20 nM at pH 6.0, with a higher range of IC50 values (0.8-80 nM) observed at pH 7.4. P-2 renin Homo sapiens