Title : The effects of oxidizing and cysteine-reactive reagents on the inward rectifier potassium channels Kir2.3 and Kir1.1.

Pub. Date : 1999 Nov

PMID : 10591077






3 Functional Relationships(s)
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1 In this study, we have investigated the roles of these extracellular cysteine residues in mediating inhibition of the Kir2.3 channel by the cysteine-reactive reagents para-chloromercuribenzenesulphonate (PCMBS) and thimerosal, and the oxidizing agent hydrogen peroxide (H2O2). PCMBS potassium inwardly rectifying channel subfamily J member 4 S homeolog Xenopus laevis
2 Wild-type Kir2.3 currents were significantly inhibited by PCMBS, thimerosal and H2O2. PCMBS potassium inwardly rectifying channel subfamily J member 4 S homeolog Xenopus laevis
3 Currents for mutants Kir2.3 C79S and C140S were also inhibited by PCMBS, thimerosal and H2O2. PCMBS potassium inwardly rectifying channel subfamily J member 4 S homeolog Xenopus laevis