Pub. Date : 1999 Dec 10
PMID : 10585470
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 2 | These findings suggest a constitutive association of SHP-1 and p62(DOK) that is either conformation-dependent or indirect as well as a direct, inducible association of the SHP-1 catalytic domain with tyrosine-phosphorylated p62(DOK). | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 3 | Thus, p62(DOK) is a major SHP-1 substrate whose tyrosine phosphorylation correlates with growth factor-independent survival in macrophages. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |