Pub. Date : 1999 Oct
PMID : 10583025
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The aim of the present study was to screen grapefruit juice components against the CYP3A4-mediated metabolism and P-gp mediated transport of the HIV-1 protease inhibitor saquinavir. | Saquinavir | phosphoglycolate phosphatase | Homo sapiens |
2 | These compounds were also screened as modulators of P-gp activity by assessing the directional transport of saquinavir across Caco-2 cell monolayers which express P-gp. | Saquinavir | phosphoglycolate phosphatase | Homo sapiens |
3 | CONCLUSIONS: Grapefruit juice components inhibit CYP3A4-mediated saquinavir metabolism and also modulate, to a limited extent, P-gp mediated saquinavir transport in Caco-2 cell monolayers. | Saquinavir | phosphoglycolate phosphatase | Homo sapiens |