Title : Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase.

Pub. Date : 1999 Nov 4

PMID : 10579835






2 Functional Relationships(s)
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1 These results demonstrate the effects of the carboxylate group orientation and the stereochemistry of the amino and carboxylate groups on the substrate activity and inhibitor activity, and this should be important to the future design of inhibitors of GABA-AT. carboxylate 4-aminobutyrate aminotransferase Homo sapiens
2 These results demonstrate the effects of the carboxylate group orientation and the stereochemistry of the amino and carboxylate groups on the substrate activity and inhibitor activity, and this should be important to the future design of inhibitors of GABA-AT. carboxylate 4-aminobutyrate aminotransferase Homo sapiens