Title : Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

Pub. Date : 1999 Dec 1

PMID : 10567237






1 Functional Relationships(s)
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Protein Name
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1 The high-affinity interaction of integrin alpha5beta1 with the central cell-binding domain of fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the tenth type III repeat) and a second site Pro-His-Ser-Arg-Asn (PHSRN) in the adjacent ninth type III repeat, which synergizes with RGD. Aspartic Acid fibronectin 1 Homo sapiens