Title : Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts.

Pub. Date : 1999 May

PMID : 10559863






1 Functional Relationships(s)
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1 Here we show that the growth of microtubules induced in fibroblasts by removal of the microtubule destabilizer nocodazole activates Rac1 GTPase, leading to the polymerization of actin in lamellipodial protrusions. Nocodazole Rac family small GTPase 1 Homo sapiens