Title : Quantitative and qualitative signals determine T-cell cycle entry and progression.

Pub. Date : 1999 Oct 10

PMID : 10555992






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The competent state (that is, the capacity to proliferate in response to exogenous IL-2) was characterized by calcium mobilization, a protein kinase C-dependent internalization of CD3, increased mitogen-activated protein kinase (MAPK) activity, transient translocation of AP-1 transcription factors to the nucleus, expression of immediate early genes, activation of G1-phase cyclin-dependent kinases, and increased CD25 (IL-2Ralpha) expression. Calcium interleukin 2 Homo sapiens