Title : Renal targeting of arginine-vasopressin by modification with carbohydrates at the tyrosine side chain.

Pub. Date : 1999 Oct

PMID : 10549862






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1 To extend the utility of a renal targeting system using carbohydrate derivatives, we investigated the in vivo tissue distribution in rats of arginine-vasopressin (AVP) derivatives modified at the phenolic hydroxy group of tyrosine by linking it to some sugars, namely D-glucose, D-galactose, D-mannose and L-fucose, via an octamethylene group. Tyrosine arginine vasopressin Rattus norvegicus